|Birth||(1909-12-07)December 7, 1909 New York, United States|
|Birth Place||New York, United States|
|Death||(1997-04-24)(aged 87) Rochester, New York, United States|
|Died At||Rochester, New York, United States|
|Alma Mater||Hamilton College, Cornell University|
|Fields||Organic chemistry, biochemistry|
,University of Rochester(1941–retirement)
|Thesis||Study of dihydrofurans and the dehydration rearrangement of 2,3-ethylenic 1,4-diols.(1935)|
|Famous Research||Dounce homogenizer; co-discovery ofcatalasecrystallization||Doctoral Advisor||James B. Sumner|
Events Occured in Scienctist Life
Alexander Dounce was born on December 7, 1909, in New York.
Dounce received his PhD in organic chemistry in 1935, the title of his thesis being "Study of dihydrofurans and the dehydration rearrangement of 2,3-ethylenic 1,4-diols".
Together with Sumner, he achieved the first crystallization of the enzyme catalase in 1937.
In 1941, Dounce moved to the Department of Biochemistry at University of Rochester Medical School, where he worked on the mechanism of uranium poisoning for the Manhattan Project.
In 1952, Alexander Dounce and Ernest Kay, who was Dounce's first PhD student, published a new method for DNA isolation and purification from nuclei employing sodium dodecyl sulfate that became widely used.
Also in 1952, Dounce wrote a review article in which he, as one of the first scientists to do so, proposed that DNA might serve as a template for the synthesis of RNA, which in turn serves as a template for the synthesis of proteins.
However, it was not until 1958, when Crick coined the term central dogma and described the concept in more detail, that it gained widespread acceptance.
When James D. Watson and George Gamow founded the RNA Tie Club in 1954, Dounce became one of its members; his designation was GLN (glutamine).
Dounce's work on the isolation of cellular organelles, particularly nuclei and mitochondria, led to the development of the Dounce homogenizers in 1954.
When Dounce's former mentor, James B. Sumner, died in 1955, Dounce wrote Sumner's obituary in Nature.
Dounce died on April 24, 1997, in Rochester, New York.